Disorders of lung matrix remodeling
Harold A. Chapman
Harold A. Chapman
Published January 15, 2004
Citation Information: J Clin Invest. 2004;113(2):148-157. https://doi.org/10.1172/JCI20729.
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Category: Science in Medicine

Disorders of lung matrix remodeling

Abstract

A set of lung diseases share the tendency for the development of progressive fibrosis ultimately leading to respiratory failure. This review examines the common pathogenetic features of these disorders in light of recent observations in both humans and animal models of disease, which reveal important pathways of lung matrix remodeling.

Authors

Harold A. Chapman

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Figure 1

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Photomicrographs of active matrix remodeling in: (a) UIP, (b) BO, and (c...
Photomicrographs of active matrix remodeling in: (a) UIP, (b) BO, and (c) COP. Filled arrows point to areas of active matrix remodeling in each disorder. Open arrows point to airway or alveolar epithelial cells overlying the remodeling matrix. Images were kindly provided by Kirk Jones, Department of Pathology, University of California, San Francisco, San Francisco, California, USA. Magnifications: (a, b) ×400; (c) ×100.