[HTML][HTML] HIV persistence in lymph nodes
R Banga, O Munoz, M Perreau - Current Opinion in HIV and AIDS, 2021 - journals.lww.com
R Banga, O Munoz, M Perreau
Current Opinion in HIV and AIDS, 2021•journals.lww.comHIV persistence in blood and distinct body compartments despite long-standing and potent
therapy is one of the major barriers to a cure. Given that the HIV reservoir is established
early and is highly complex based on composition, viral diversity, distribution, replication
competence, migration dynamics across the human body and possible
compartmentalization in specific tissues, combinatorial therapeutic approaches are needed
that may synergize to target multiple viral reservoirs to achieve a cure for HIV infection.
therapy is one of the major barriers to a cure. Given that the HIV reservoir is established
early and is highly complex based on composition, viral diversity, distribution, replication
competence, migration dynamics across the human body and possible
compartmentalization in specific tissues, combinatorial therapeutic approaches are needed
that may synergize to target multiple viral reservoirs to achieve a cure for HIV infection.
Summary
HIV persistence in blood and distinct body compartments despite long-standing and potent therapy is one of the major barriers to a cure. Given that the HIV reservoir is established early and is highly complex based on composition, viral diversity, distribution, replication competence, migration dynamics across the human body and possible compartmentalization in specific tissues, combinatorial therapeutic approaches are needed that may synergize to target multiple viral reservoirs to achieve a cure for HIV infection.
Lippincott Williams & Wilkins