[HTML][HTML] DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair
N Tomimatsu, B Mukherjee, JL Harris, FL Boffo… - Journal of Biological …, 2017 - ASBMB
End resection of DNA double-strand breaks (DSBs) to generate 3′-single-stranded DNA
facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair
by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end
resection involves phosphorylation of the 5′ to 3′ exonuclease EXO1 by the
phosphoinositide 3-kinase-like kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM
and Rad3-related) and by the cyclin-dependent kinases 1 and 2. After activation, EXO1 must …
facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair
by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end
resection involves phosphorylation of the 5′ to 3′ exonuclease EXO1 by the
phosphoinositide 3-kinase-like kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM
and Rad3-related) and by the cyclin-dependent kinases 1 and 2. After activation, EXO1 must …