[HTML][HTML] The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast
Cumulative evidence suggests that non-proteolytic functions of the proteasome are involved
in transcriptional regulation, mRNA export, and ubiquitin-dependent histone modification
and thereby modulate the intracellular levels of regulatory proteins implicated in controlling
key cellular functions. To date, the non-proteolytic roles of the proteasome have been mainly
investigated in euchromatin; their effects on heterochromatin are largely unknown. Here,
using fission yeast as a model, we randomly mutagenized the subunits of the 19S …
in transcriptional regulation, mRNA export, and ubiquitin-dependent histone modification
and thereby modulate the intracellular levels of regulatory proteins implicated in controlling
key cellular functions. To date, the non-proteolytic roles of the proteasome have been mainly
investigated in euchromatin; their effects on heterochromatin are largely unknown. Here,
using fission yeast as a model, we randomly mutagenized the subunits of the 19S …