Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART
RE Nettles, TL Kieffer, P Kwon, D Monie, Y Han… - Jama, 2005 - jamanetwork.com
ContextMany patients infected with human immunodeficiency virus type 1 (HIV-1) and
receiving highly active antiretroviral therapy experience intermittent episodes of detectable
viremia (“blips”), which may raise concerns about drug resistance, lead to costly repeat
measurements of viral RNA, and sometimes trigger alterations in therapy. ObjectiveTo test
the hypothesis that blips represent random biological and statistical variation around mean
steady-state HIV-1 RNA levels slightly below 50 copies/mL rather than biologically …
receiving highly active antiretroviral therapy experience intermittent episodes of detectable
viremia (“blips”), which may raise concerns about drug resistance, lead to costly repeat
measurements of viral RNA, and sometimes trigger alterations in therapy. ObjectiveTo test
the hypothesis that blips represent random biological and statistical variation around mean
steady-state HIV-1 RNA levels slightly below 50 copies/mL rather than biologically …