The roles of viruses in brain tumor initiation and oncomodulation

A Kofman, L Marcinkiewicz, E Dupart… - Journal of neuro …, 2011 - Springer
A Kofman, L Marcinkiewicz, E Dupart, A Lyshchev, B Martynov, A Ryndin, E Kotelevskaya…
Journal of neuro-oncology, 2011Springer
While some avian retroviruses have been shown to induce gliomas in animal models,
human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the
much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract
more and more attention as possible contributing or initiating factors in the development of
human brain tumors. The aim of this review is to summarize and highlight the most
provoking findings indicating a potential causative link between brain tumors, specifically …
Abstract
While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.
Springer