In vitro neurosphere formation correlates with poor survival in glioma
P C. Jayakrishnan, E H. Venkat… - IUBMB …, 2019 - Wiley Online Library
Sphere formation is an indicator of tumor aggressiveness independent of the tumor grade;
however, its relation to progression‐free survival (PFS) is less known. This study was
designed to assess the neurosphere forming ability among low grade glioma (LGG) and
high‐grade glioma (HGG), its stem cell marker expression, and correlation to PFS. Tumor
samples of 140 patients, including (LGG; n= 67) and (HGG; n= 73) were analyzed. We used
sphere forming assay, immunofluorescence, and immunohistochemistry to characterize the …
however, its relation to progression‐free survival (PFS) is less known. This study was
designed to assess the neurosphere forming ability among low grade glioma (LGG) and
high‐grade glioma (HGG), its stem cell marker expression, and correlation to PFS. Tumor
samples of 140 patients, including (LGG; n= 67) and (HGG; n= 73) were analyzed. We used
sphere forming assay, immunofluorescence, and immunohistochemistry to characterize the …
[CITATION][C] In Vitro Neurosphere Formation Correlates with Poor Survival in Glioma
GR Menon - IUBMB Life, 2018