[HTML][HTML] eIF4A2 is a host factor required for efficient HIV-1 replication
JK Ndzinu, H Takeuchi, H Saito, T Yoshida… - Microbes and …, 2018 - Elsevier
Host factors are required for efficient HIV-1 replication. To identify these factors, genome-
wide RNA interference screening was performed using a human T cell line. In the present
study, we assessed whether eukaryotic translation initiation factor 4A isoform 2 (eIF4A2), a
DEAD-box protein identified in our screen, is necessary for efficient HIV-1 replication.
Exploiting MT4C5 cells depleted of eIF4A2 by stable expression of eIF4A2-specific short-
hairpin RNA (shRNA) using a lentiviral system, we found that depletion of eIF4A2 markedly …
wide RNA interference screening was performed using a human T cell line. In the present
study, we assessed whether eukaryotic translation initiation factor 4A isoform 2 (eIF4A2), a
DEAD-box protein identified in our screen, is necessary for efficient HIV-1 replication.
Exploiting MT4C5 cells depleted of eIF4A2 by stable expression of eIF4A2-specific short-
hairpin RNA (shRNA) using a lentiviral system, we found that depletion of eIF4A2 markedly …