[HTML][HTML] Leukocyte subtype counts and its association with vascular structure and function in adults with intermediate cardiovascular risk. MARK study
L Gomez-Sanchez, L Garcia-Ortiz… - PLoS …, 2015 - journals.plos.org
PLoS One, 2015•journals.plos.org
Objectives We investigated the relationship between leukocyte subtype counts and vascular
structure and function based on carotid intima-media thickness, pulse wave velocity, central
augmentation index and cardio-ankle vascular index by gender in intermediate
cardiovascular risk patients. Methods This study analyzed 500 subjects who were included
in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women. Measurement:
Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular …
structure and function based on carotid intima-media thickness, pulse wave velocity, central
augmentation index and cardio-ankle vascular index by gender in intermediate
cardiovascular risk patients. Methods This study analyzed 500 subjects who were included
in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women. Measurement:
Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular …
Objectives
We investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients.
Methods
This study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women. Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx).
Results
Total leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (β = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (β = 2.445, p = 0.022) in women.
Conclusion
The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders.
Trial Registration
ClinicalTrials.gov NCT01428934
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