[HTML][HTML] TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway
C Jousse, C Deval, AC Maurin, L Parry… - Journal of Biological …, 2007 - ASBMB
The integrated stress response (ISR) is defined as a highly conserved response to several
stresses that converge to the induction of the activating transcription factor 4 (ATF4).
Because an uncontrolled response may have deleterious effects, cells have elaborated
several negative feedback loops that attenuate the ISR. In the present study, we describe
how induction of the human homolog of Drosophila tribbles (TRB3) attenuates the ISR by a
negative feedback mechanism. To investigate the role of TRB3 in the control of the ISR, we …
stresses that converge to the induction of the activating transcription factor 4 (ATF4).
Because an uncontrolled response may have deleterious effects, cells have elaborated
several negative feedback loops that attenuate the ISR. In the present study, we describe
how induction of the human homolog of Drosophila tribbles (TRB3) attenuates the ISR by a
negative feedback mechanism. To investigate the role of TRB3 in the control of the ISR, we …