Ribonuclease 7 shields the kidney and bladder from invasive uropathogenic Escherichia coli infection
T Eichler, K Bender, MJ Murtha… - Journal of the …, 2019 - journals.lww.com
Background Evidence suggests that antimicrobial peptides, components of the innate
immune response, protect the kidneys and bladder from bacterial challenge. We previously
identified ribonuclease 7 (RNase 7) as a human antimicrobial peptide that has bactericidal
activity against uropathogenic Escherichia coli (UPEC). Functional studies assessing RNase
7's contributions to urinary tract defense are limited. Methods To investigate RNase 7's role
in preventing urinary tract infection (UTI), we quantified urinary RNase 7 concentrations in …
immune response, protect the kidneys and bladder from bacterial challenge. We previously
identified ribonuclease 7 (RNase 7) as a human antimicrobial peptide that has bactericidal
activity against uropathogenic Escherichia coli (UPEC). Functional studies assessing RNase
7's contributions to urinary tract defense are limited. Methods To investigate RNase 7's role
in preventing urinary tract infection (UTI), we quantified urinary RNase 7 concentrations in …
