Kaposi sarcoma associated herpesvirus (KSHV), a γ2-herpesvirus, also known as human
herpesvirus-8, is the etiologic agent of three virally associated tumors: Kaposi sarcoma, a
plasmablastic form of multicentric Castleman disease (KSHV-MCD), and primary effusion
lymphoma. These malignancies are predominantly seen in people with acquired
immunodeficiencies, including acquired immunodeficiency syndrome and iatrogenic
immunosuppression in the setting of organ transplantation, but can also develop in the …