Disrupting reconsolidation seems to be a promising approach to dampen the expression of
fear memory. Recently, we demonstrated that disrupting reconsolidation by a
pharmacological manipulation specifically targeted the emotional expression of memory (ie,
startle response). Here we test in a human differential fear-conditioning paradigm with fear-
relevant stimuli whether the spacing of a single unreinforced retrieval trial relative to
extinction learning allows for “rewriting” the original fear association, thereby preventing the …