[HTML][HTML] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
A Bartholomew, C Sturgeon, M Siatskas, K Ferrer… - Experimental …, 2002 - Elsevier
OBJECTIVE: Mesenchymal stem cells (MSCs), multipotential cells that reside within the
bone marrow, can be induced to differentiate into various components of the marrow
microenvironment, such as bone, adipose, and stromal tissues. The bone marrow
microenvironment is vital to the development, differentiation, and regulation of the
lymphohematopoietic system. We hypothesized that the activities of MSCs in the bone
marrow microenvironment might also include immunomodulatory effects on lymphocytes …
bone marrow, can be induced to differentiate into various components of the marrow
microenvironment, such as bone, adipose, and stromal tissues. The bone marrow
microenvironment is vital to the development, differentiation, and regulation of the
lymphohematopoietic system. We hypothesized that the activities of MSCs in the bone
marrow microenvironment might also include immunomodulatory effects on lymphocytes …
