A novel mode of FoxM1 regulation: positive auto-regulatory loop
M Halasi, AL Gartel - Cell Cycle, 2009 - Taylor & Francis
M Halasi, AL Gartel
Cell Cycle, 2009•Taylor & FrancisOncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight
against cancer, because it is overexpressed in a majority of human tumors. Previously, we
identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of
the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-
regulation of FoxM1.
against cancer, because it is overexpressed in a majority of human tumors. Previously, we
identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of
the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-
regulation of FoxM1.
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.
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