Src homology 2 domain–containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung
BACKGROUND: Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP-1)
controls the intracellular level of the phosphoinositide 3–kinase product phosphotidylinositol-
3, 4, 5-trisphosphate and functions as a negative regulator of cytokine and immune receptor
signaling. Emerging evidence suggests that the phosphoinositide 3-kinase pathway might
be involved in allergic inflammation in the lung. However, the functional relevance of SHIP-1
in the TH2 activation pathway has not been established. SHIP-1−/− mice have spontaneous …
controls the intracellular level of the phosphoinositide 3–kinase product phosphotidylinositol-
3, 4, 5-trisphosphate and functions as a negative regulator of cytokine and immune receptor
signaling. Emerging evidence suggests that the phosphoinositide 3-kinase pathway might
be involved in allergic inflammation in the lung. However, the functional relevance of SHIP-1
in the TH2 activation pathway has not been established. SHIP-1−/− mice have spontaneous …
