[HTML][HTML] Regulatory T cell infusion can enhance memory T cell and alloantibody responses in lymphodepleted nonhuman primate heart allograft recipients
MB Ezzelarab, H Zhang, H Guo, L Lu… - American Journal of …, 2016 - Elsevier
The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant
tolerance in lymphodepleted rodents is well established. Few studies, however, have
addressed the therapeutic potential of adoptively transferred, CD4+ CD25+ CD127−
Foxp3+(Treg) in clinically relevant large animal models. We infused ex vivo–expanded,
functionally stable, nonselected Treg (up to a maximum cumulative dose of 1.87 billion cells)
into antithymocyte globulin–lymphodepleted, MHC‐mismatched cynomolgus monkey heart …
tolerance in lymphodepleted rodents is well established. Few studies, however, have
addressed the therapeutic potential of adoptively transferred, CD4+ CD25+ CD127−
Foxp3+(Treg) in clinically relevant large animal models. We infused ex vivo–expanded,
functionally stable, nonselected Treg (up to a maximum cumulative dose of 1.87 billion cells)
into antithymocyte globulin–lymphodepleted, MHC‐mismatched cynomolgus monkey heart …