[HTML][HTML] Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer
Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg)
immunotherapy to the clinic. These include a determination of their pharmacokinetic
characteristics, their optimal dose, their phenotypic stability and the best therapies with
which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we
determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large
(75±11× 10 6 Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of …
immunotherapy to the clinic. These include a determination of their pharmacokinetic
characteristics, their optimal dose, their phenotypic stability and the best therapies with
which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we
determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large
(75±11× 10 6 Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of …