[HTML][HTML] Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation

A Mazharian, SP Watson, S Séverin - Experimental hematology, 2009 - Elsevier
OBJECTIVE: Megakaryopoiesis and platelet formation is a multistep process through which
hematopoietic progenitor cells develop into mature megakaryocytes (MKs) and form
proplatelets. The present study investigates the regulation of different steps of
megakaryopoiesis (ie, differentiation, migration, and proplatelet formation) by extracellar
signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) in two
models of primary murine MKs derived from bone marrow (BM) cells and fetal liver (FL) cells …