The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

KI Hilgendorf, CT Johnson, PK Jackson - Current opinion in cell biology, 2016 - Elsevier
Current opinion in cell biology, 2016Elsevier
The primary cilium is an antenna-like cellular protrusion mediating sensory and
neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia-
localized receptors, in particular G-protein-coupled receptors, determine a host of crucial
physiologies, which are disrupted in human ciliopathies. Here, we discuss recent advances
in the identification and characterization of ciliary signaling components and pathways.
Recent studies have highlighted the unique signaling environment of the primary cilium and …
The primary cilium is an antenna-like cellular protrusion mediating sensory and neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia-localized receptors, in particular G-protein-coupled receptors, determine a host of crucial physiologies, which are disrupted in human ciliopathies. Here, we discuss recent advances in the identification and characterization of ciliary signaling components and pathways. Recent studies have highlighted the unique signaling environment of the primary cilium and we are just beginning to understand how this design allows for highly amplified and regulated signaling.
Elsevier