Chikungunya virus: evolution and genetic determinants of emergence
KA Tsetsarkin, R Chen, MB Sherman… - Current opinion in …, 2011 - Elsevier
Chikungunya virus (CHIKV) causes a severe and often persistent arthralgic disease that is
occasionally fatal. A mosquito-borne virus, CHIKV exists in enzootic, nonhuman primate
cycles in Africa, but occasionally emerges into urban, human cycles to cause major
epidemics. Between 1920 and 1950, and again in 2005, CHIKV emerged into India and
Southeast Asia, where major urban epidemics ensued. Unlike the early introduction, the
2005 emergence was accompanied by an adaptive mutation that allowed CHIKV to exploit a …
occasionally fatal. A mosquito-borne virus, CHIKV exists in enzootic, nonhuman primate
cycles in Africa, but occasionally emerges into urban, human cycles to cause major
epidemics. Between 1920 and 1950, and again in 2005, CHIKV emerged into India and
Southeast Asia, where major urban epidemics ensued. Unlike the early introduction, the
2005 emergence was accompanied by an adaptive mutation that allowed CHIKV to exploit a …