p-Cresyl sulfate promotes insulin resistance associated with CKD

L Koppe, NJ Pillon, RE Vella, ML Croze… - Journal of the …, 2013 - journals.lww.com
The mechanisms underlying the insulin resistance that frequently accompanies CKD are
poorly understood, but the retention of renally excreted compounds may play a role. One
such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from
tyrosine metabolism by intestinal microbes. Here, we sought to determine whether PCS
contributes to CKD-associated insulin resistance. Administering PCS to mice with normal
kidney function for 4 weeks triggered insulin resistance, loss of fat mass, and ectopic …