The distribution of lanthanum in tight junctions of the kidney tubule

A Martinez-Palomo, D Erlij - Pflügers Archiv, 1973 - Springer
Pflügers Archiv, 1973Springer
The penetration of either “ionic” or “colloidal” lanthanum into the tight junctions of different
tubular segments of the rat kidney was studied with the electron microscope. After perfusing
the tracer through the aorta it was found that “ionic” and “colloidal” lanthanum penetrated the
tight junctions of both the proximal and distal convoluted tubules, while the junctions of the
collecting tubules were free of tracer. An attempt to correlate junctional tightness and
electrical resistance in these epithelia is presented.
Summary
The penetration of either “ionic” or “colloidal” lanthanum into the tight junctions of different tubular segments of the rat kidney was studied with the electron microscope. After perfusing the tracer through the aorta it was found that “ionic” and “colloidal” lanthanum penetrated the tight junctions of both the proximal and distal convoluted tubules, while the junctions of the collecting tubules were free of tracer. An attempt to correlate junctional tightness and electrical resistance in these epithelia is presented.
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