[HTML][HTML] Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

RJ Appelhoff, YM Tian, RR Raval, H Turley… - Journal of Biological …, 2004 - ASBMB
Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many
aspects of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis
of its α-subunits, following oxygen-dependent hydroxylation of specific prolyl residues.
Although three HIF prolyl hydroxylases, PHD1, PHD2, and PHD3, have been identified that
have the potential to catalyze this reaction, the contribution of each isoform to the
physiological regulation of HIF remains uncertain. Here we show using suppression by …