Characteristics of autoantibodies to human interferon in a patient with varicella-zoster disease
B Pozzetto, KE Mogensen, MG Tovey… - Journal of Infectious …, 1984 - academic.oup.com
B Pozzetto, KE Mogensen, MG Tovey, I Gresser
Journal of Infectious Diseases, 1984•academic.oup.comA patient with varicella-zoster disease was found to have antibodies to human interferon.
These antibodies included all IgG subclasses, showed a high combined affinity (average
dissociation constant, 10− 11 M), and were present in serum at a concentration of 10− 9 M.
The antibodies neutralized the activity of a series of human α-interferons prepared from
recombinant DNA as well as that of naturally occurring mixtures of α-type interferon
prepared by viral stimulation of human cells. Examination of the patient's lymphoid cells …
These antibodies included all IgG subclasses, showed a high combined affinity (average
dissociation constant, 10− 11 M), and were present in serum at a concentration of 10− 9 M.
The antibodies neutralized the activity of a series of human α-interferons prepared from
recombinant DNA as well as that of naturally occurring mixtures of α-type interferon
prepared by viral stimulation of human cells. Examination of the patient's lymphoid cells …
Abstract
A patient with varicella-zoster disease was found to have antibodies to human interferon. These antibodies included all IgG subclasses, showed a high combined affinity (average dissociation constant, 10−11M), and were present in serum at a concentration of 10−9M. The antibodies neutralized the activity of a series of human α-interferons prepared from recombinant DNA as well as that of naturally occurring mixtures of α-type interferon prepared by viral stimulation of human cells. Examination of the patient's lymphoid cells revealed normal production of interferon and normal expression of interferon receptors. Interferon from the patient's cells was neutralized by her serum. The neutralizing capacity of this serum was analyzed with regard to levels of interferon previously detected in patients with varicella-zoster infections.
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