Antibodies to human leucocyte interferons in cancer patients
PW Trown, RA Dennin JR, MJ Kramer, EV Connell… - The Lancet, 1983 - Elsevier
PW Trown, RA Dennin JR, MJ Kramer, EV Connell, AV Palleroni, J Quesada, JU Gutterman
The Lancet, 1983•ElsevierDuring the course of clinical investigation of partly purified human leucocyte interferon (IFN)
prepared at the Finnish Red Cross (PIF), neutralising IgG antibodies to human leucocyte IFN
were detected in the sera of 3 patients with cancer. In 2 of these patients, the antibodies
were detected in serum before treatment with PIF. In the third patient antibodies developed
during the course of treatment. Antibody titres against six recombinant human leucocyte IFN
sub-types and one recombinant hybrid human leucocyte IFN were different in the 3 patients.
prepared at the Finnish Red Cross (PIF), neutralising IgG antibodies to human leucocyte IFN
were detected in the sera of 3 patients with cancer. In 2 of these patients, the antibodies
were detected in serum before treatment with PIF. In the third patient antibodies developed
during the course of treatment. Antibody titres against six recombinant human leucocyte IFN
sub-types and one recombinant hybrid human leucocyte IFN were different in the 3 patients.
Abstract
During the course of clinical investigation of partly purified human leucocyte interferon (IFN) prepared at the Finnish Red Cross (PIF), neutralising IgG antibodies to human leucocyte IFN were detected in the sera of 3 patients with cancer. In 2 of these patients, the antibodies were detected in serum before treatment with PIF. In the third patient antibodies developed during the course of treatment. Antibody titres against six recombinant human leucocyte IFN sub-types and one recombinant hybrid human leucocyte IFN were different in the 3 patients.
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