Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis
A Coulomb-L'Hermine, F Capron, W Zou, F Piard… - Human pathology, 2001 - Elsevier
Wegener's granulomatosis (WG) is an inflammatory, destructive, angiotropic lesion. The
inflammatory process involves accumulation of macrophages, lymphocytes, and
polymorphonuclear neutrophils. We studied 6 lung biopsy specimens from patients with WG
to characterize the cellular infiltrate and to analyze the mechanism of immune cell
recruitment. We show that lymphocytes accumulating in WG lesions are mostly memory
CD4+ CD45RO+ T lymphocytes and, although less numerous, CD8+ CD45RO+ T …
inflammatory process involves accumulation of macrophages, lymphocytes, and
polymorphonuclear neutrophils. We studied 6 lung biopsy specimens from patients with WG
to characterize the cellular infiltrate and to analyze the mechanism of immune cell
recruitment. We show that lymphocytes accumulating in WG lesions are mostly memory
CD4+ CD45RO+ T lymphocytes and, although less numerous, CD8+ CD45RO+ T …
