Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role
I Espinosa, MJ Carnicer, L Catasus… - The American journal …, 2010 - journals.lww.com
Myometrial invasion is an independent prognostic parameter of the endometrioid
carcinomas which correlates with the risk of metastasis to pelvic and/or paraaortic lymph
nodes. Recognition of myometrial invasion is sometimes difficult. In fact, myoinvasion is
overdiagnosed in routine practice in as many as 25% of the cases. Recently, it has been
observed that tumor-associated macrophages stimulate angiogenesis and promote cancer
dissemination. Tumor macrophages (CD163), microvessel density (CD31), and hypoxia …
carcinomas which correlates with the risk of metastasis to pelvic and/or paraaortic lymph
nodes. Recognition of myometrial invasion is sometimes difficult. In fact, myoinvasion is
overdiagnosed in routine practice in as many as 25% of the cases. Recently, it has been
observed that tumor-associated macrophages stimulate angiogenesis and promote cancer
dissemination. Tumor macrophages (CD163), microvessel density (CD31), and hypoxia …
