Evaluation of 6-([18F] fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
AE Reid, J Hooker, E Shumay, J Logan, C Shea… - Nuclear medicine and …, 2009 - Elsevier
INTRODUCTION: Histone deacetylases (HDACs) are enzymes involved in epigenetic
modifications that shift the balance toward chromatin condensation and silencing of gene
expression. Here, we evaluate the utility of 6-([18F] fluoroacetamido)-1-hexanoicanilide
([18F] FAHA) for positron emission tomography imaging of HDAC activity in the baboon
brain. For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition,
metabolic stability and the distribution of the putative metabolite [18F] fluoroacetate ([18F] …
modifications that shift the balance toward chromatin condensation and silencing of gene
expression. Here, we evaluate the utility of 6-([18F] fluoroacetamido)-1-hexanoicanilide
([18F] FAHA) for positron emission tomography imaging of HDAC activity in the baboon
brain. For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition,
metabolic stability and the distribution of the putative metabolite [18F] fluoroacetate ([18F] …