Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease
D Zheng, M Wolfe, BD Cowley Jr… - Journal of the …, 2003 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) progresses to renal insufficiency
in> 50% of patients and is characterized by interstitial inflammation and fibrosis in the end
stage. In a rat model of ADPKD, monocytes accumulate within the renal interstitium in
association with increased levels of monocyte chemoattractant protein-1 (MCP-1) in cyst
mural cells and increased excretion of this chemokine into the urine. For determining the
extent to which this chemokine is abnormally expressed in patients with ADPKD, a cross …
in> 50% of patients and is characterized by interstitial inflammation and fibrosis in the end
stage. In a rat model of ADPKD, monocytes accumulate within the renal interstitium in
association with increased levels of monocyte chemoattractant protein-1 (MCP-1) in cyst
mural cells and increased excretion of this chemokine into the urine. For determining the
extent to which this chemokine is abnormally expressed in patients with ADPKD, a cross …