Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart
P Zhang, U Mende - Trends in cardiovascular medicine, 2014 - Elsevier
G protein-mediated signal transduction is essential for the regulation of cardiovascular
function, including heart rate, growth, contraction, and vascular tone. Regulators of G protein
Signaling (RGS proteins) fine-tune G protein-coupled receptor-induced signaling by
regulating its magnitude and duration through direct interaction with the α subunits of
heterotrimeric G proteins. Changes in the RGS protein expression and/or function in the
heart often lead to pathophysiological changes and are associated with cardiac disease in …
function, including heart rate, growth, contraction, and vascular tone. Regulators of G protein
Signaling (RGS proteins) fine-tune G protein-coupled receptor-induced signaling by
regulating its magnitude and duration through direct interaction with the α subunits of
heterotrimeric G proteins. Changes in the RGS protein expression and/or function in the
heart often lead to pathophysiological changes and are associated with cardiac disease in …