TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels
TD Plant, M Schaefer - Cell calcium, 2003 - Elsevier
The seven mammalian channels from the classical (TRPC) subfamily of transient receptor
potential (TRP) channels are thought to be receptor-operated cation channels activated in a
phospholipase C (PLC)-dependent manner. Based on sequence similarity, TRPC channels
can be divided into four subgroups. Group 4 comprises TRPC4 and TRPC5, and is most
closely related to group 1 (TRPC1). The functional properties observed following
heterologous expression of TRPC4 or TRPC5 in mammalian cells are contradictory and …
potential (TRP) channels are thought to be receptor-operated cation channels activated in a
phospholipase C (PLC)-dependent manner. Based on sequence similarity, TRPC channels
can be divided into four subgroups. Group 4 comprises TRPC4 and TRPC5, and is most
closely related to group 1 (TRPC1). The functional properties observed following
heterologous expression of TRPC4 or TRPC5 in mammalian cells are contradictory and …