Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?
MP Winn, N Daskalakis, RF Spurney… - Journal of the …, 2006 - journals.lww.com
Focal and segmental glomerulosclerosis (FSGS) is a lead-ing cause of glomerulonephritis
and chronic kidney disease (CKD) in children and young adults (1). As much as one fifth of
the ESRD population carries this diagnosis, and the proportion of ESRD attributed to FSGS
has increased more than 10-fold over the past two decades (2). The glomerular landmarks
of FSGS can develop secondary to a variety of systemic conditions, including disorders that
cause chronic hypoxemia, processes that augment glomerular blood flow, and diseases that …
and chronic kidney disease (CKD) in children and young adults (1). As much as one fifth of
the ESRD population carries this diagnosis, and the proportion of ESRD attributed to FSGS
has increased more than 10-fold over the past two decades (2). The glomerular landmarks
of FSGS can develop secondary to a variety of systemic conditions, including disorders that
cause chronic hypoxemia, processes that augment glomerular blood flow, and diseases that …