[HTML][HTML] Molecular cloning of mouse type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors and identification of a novel type 2 receptor splice variant
M Iwai, Y Tateishi, M Hattori, A Mizutani… - Journal of Biological …, 2005 - ASBMB
We isolated cDNAs encoding type 2 and type 3 inositol 1, 4, 5-trisphosphate (IP 3) receptors
(IP 3 R2 and IP 3 R3, respectively) from mouse lung and found a novel alternative splicing
segment, SI m2, at 176–208 of IP 3 R2. The long form (IP 3 R2 SI m2+) was dominant, but
the short form (IP 3 R2 SI m2–) was detected in all tissues examined. IP 3 R2 SI m2–has
neither IP 3 binding activity nor Ca 2+ releasing activity. In addition to its reticular
distribution, IP 3 R2 SI m2+ is present in the form of clusters in the endoplasmic reticulum of …
(IP 3 R2 and IP 3 R3, respectively) from mouse lung and found a novel alternative splicing
segment, SI m2, at 176–208 of IP 3 R2. The long form (IP 3 R2 SI m2+) was dominant, but
the short form (IP 3 R2 SI m2–) was detected in all tissues examined. IP 3 R2 SI m2–has
neither IP 3 binding activity nor Ca 2+ releasing activity. In addition to its reticular
distribution, IP 3 R2 SI m2+ is present in the form of clusters in the endoplasmic reticulum of …