Tumor draining lymph nodes form the first line of defense against tumor dissemination.
Lymphocyte subpopulations activated during anti-tumor response determine the outcome of
host-tumor interaction. In the present study we explored the percentages of different
subtypes of CD4+ lymphocytes, including regulatory cells (TFR, CD25−, and CD25+ Treg
cells), helper subsets (Th1, Th2, Th17, and Tfh cells), and the expression level of their
cognate cytokines (IFNγ, IL4, and IL17) in tumor draining lymph nodes of patients with breast …