ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers
SE Sillivan, JD Whittard, MM Jacobs, Y Ren… - Biological …, 2013 - Elsevier
Background Abuse of heroin and prescription opiate medications has grown to disturbing
levels. Opioids mediate their effects through mu opioid receptors (MOR), but minimal
information exists regarding MOR-related striatal signaling relevant to the human condition.
The striatum is a structure central to reward and habitual behavior and neurobiological
changes in this region are thought to underlie the pathophysiology of addiction disorders.
Methods We examined molecular mechanisms related to MOR in postmortem human brain …
levels. Opioids mediate their effects through mu opioid receptors (MOR), but minimal
information exists regarding MOR-related striatal signaling relevant to the human condition.
The striatum is a structure central to reward and habitual behavior and neurobiological
changes in this region are thought to underlie the pathophysiology of addiction disorders.
Methods We examined molecular mechanisms related to MOR in postmortem human brain …
