Herpes simplex virus infection in populations of mouse dorsal root ganglion neurons: effects of inoculation route and virus strain
DB Henken, JR Martin - Journal of the neurological sciences, 1991 - Elsevier
To investigate whether herpes simplex virus type-2 (HSV-2) infection of sensory ganglion
neurons is restricted to a particular neuronal class, we unilaterally inoculated either the
footpad, leg muscle or sciatic nerve of mice with strains of HSV-2 that differ in virulence and
examined the soma sizes of lumbar dorsal root ganglion (DRG) neurons containing viral
antigen near the peak of acute infection. Each inoculation route appeared relatively
selective for a different portion of the neuronal size spectrum. Footpad inoculation primarily …
neurons is restricted to a particular neuronal class, we unilaterally inoculated either the
footpad, leg muscle or sciatic nerve of mice with strains of HSV-2 that differ in virulence and
examined the soma sizes of lumbar dorsal root ganglion (DRG) neurons containing viral
antigen near the peak of acute infection. Each inoculation route appeared relatively
selective for a different portion of the neuronal size spectrum. Footpad inoculation primarily …
