A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon γ response genes
DJ Gough, K Sabapathy, EYN Ko, HA Arthur… - Journal of biological …, 2007 - ASBMB
The biological effects of interferon γ (IFNγ) are mediated by interferon-stimulated genes
(ISGs), many of which are activated downstream of Janus kinase (JAK)/signal transducer
and activator of transcription 1 (STAT1) signaling. Herein we have shown that IFNγ rapidly
activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1.
IFNγ-induced c-Jun phosphorylation and AP-1 DNA binding required the MEK1/2 and
ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen-activated protein kinase …
(ISGs), many of which are activated downstream of Janus kinase (JAK)/signal transducer
and activator of transcription 1 (STAT1) signaling. Herein we have shown that IFNγ rapidly
activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1.
IFNγ-induced c-Jun phosphorylation and AP-1 DNA binding required the MEK1/2 and
ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen-activated protein kinase …
