[HTML][HTML] Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor γ
UH Park, SK Yoon, T Park, EJ Kim, SJ Um - Journal of biological chemistry, 2011 - ASBMB
Our previous studies have suggested that the mammalian additional sex comb-like 1 protein
functions as a coactivator or repressor of retinoic acid receptors in a cell-specific manner.
Here, we investigated the roles of additional sex comb-like 1 proteins in regulating
peroxisome proliferator-activated receptors (PPARs). In pulldown assays in vitro and in
immunoprecipitation assays in vivo, ASXL1 and its paralog, ASXL2, interacted with PPARα
and PPARγ. In 3T3-L1 preadipocyte cells, overexpression of ASXL1 inhibited the induction …
functions as a coactivator or repressor of retinoic acid receptors in a cell-specific manner.
Here, we investigated the roles of additional sex comb-like 1 proteins in regulating
peroxisome proliferator-activated receptors (PPARs). In pulldown assays in vitro and in
immunoprecipitation assays in vivo, ASXL1 and its paralog, ASXL2, interacted with PPARα
and PPARγ. In 3T3-L1 preadipocyte cells, overexpression of ASXL1 inhibited the induction …
