Practical considerations for pharmaceutical antibody production in different crop systems
E Stoger, M Sack, Y Perrin, C Vaquero, E Torres… - Molecular …, 2002 - Springer
Molecular Breeding, 2002•Springer
The potential of plant cells to produce functional recombinantantibodies has been
demonstrated in a number of different plant systems. Wepresent a comparative study of a
well-defined target protein, a single chain Fvantibody, in different transgenic crop species
and cultured tissues. The effectof different regulatory elements and signals for subcellular
targeting areconsidered. Practical considerations for the choice of a particular cropsystem,
such as yield, storage, distribution and containment properties are discussed.
demonstrated in a number of different plant systems. Wepresent a comparative study of a
well-defined target protein, a single chain Fvantibody, in different transgenic crop species
and cultured tissues. The effectof different regulatory elements and signals for subcellular
targeting areconsidered. Practical considerations for the choice of a particular cropsystem,
such as yield, storage, distribution and containment properties are discussed.
Abstract
The potential of plant cells to produce functional recombinantantibodies has been demonstrated in a number of different plant systems. Wepresent a comparative study of a well-defined target protein, a single chain Fvantibody, in different transgenic crop species and cultured tissues. The effectof different regulatory elements and signals for subcellular targeting areconsidered. Practical considerations for the choice of a particular cropsystem,such as yield, storage, distribution and containment properties are discussed.
Springer