[PDF][PDF] Pivotal role of CD38 biomarker in combination with CD24, EpCAM, and ALDH for identification of H460 derived lung cancer stem cells
F Karimi-Busheri, V Zadorozhny, T Li, H Lin… - Journal of stem …, 2011 - researchgate.net
Lung cancer is the number one killer among all cancers and is estimated to kill over 170,000
individual in 2010 in the United States. However, little is understood about the role of tumor
initiating cells in the lung cancer and whether these cells play a major role in initiation, drug
resistance, and metastases of this disease. We have isolated lungospheres from tumors
grown in mice and have critically examined proposed biomarkers of lung cancer stem cells
such as ALDH, EpCAM, CD133/1, CD133/2, CD24, and CD38, using global gene …
individual in 2010 in the United States. However, little is understood about the role of tumor
initiating cells in the lung cancer and whether these cells play a major role in initiation, drug
resistance, and metastases of this disease. We have isolated lungospheres from tumors
grown in mice and have critically examined proposed biomarkers of lung cancer stem cells
such as ALDH, EpCAM, CD133/1, CD133/2, CD24, and CD38, using global gene …
