Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain
Changes in expression and function of voltage-gated sodium channels (VGSC) in dorsal
root ganglion (DRG) neurons may play a major role in the genesis of peripheral
hyperexcitability that occurs in neuropathic pain. We present here the first description of
changes induced by spared nerve injury (SNI) to Nav1 mRNA levels and tetrodotoxin-
sensitive and-resistant (TTX-S/TTX-R) Na+ currents in injured and adjacent non-injured
small DRG neurons. VGSC transcripts were down-regulated in injured neurons except for …
root ganglion (DRG) neurons may play a major role in the genesis of peripheral
hyperexcitability that occurs in neuropathic pain. We present here the first description of
changes induced by spared nerve injury (SNI) to Nav1 mRNA levels and tetrodotoxin-
sensitive and-resistant (TTX-S/TTX-R) Na+ currents in injured and adjacent non-injured
small DRG neurons. VGSC transcripts were down-regulated in injured neurons except for …
