[HTML][HTML] SDF-1–induced actin polymerization and migration in human hematopoietic progenitor cells
C Voermans, EC Anthony, E Mul… - Experimental …, 2001 - Elsevier
OBJECTIVE: The capacity of hematopoietic progenitor cells (HPCs; CD34+ cells) to respond
to chemotactic stimulation is essential for their homing efficiency, eg, during stem cell
transplantation. Previous studies established that stromal cell–derived factor-1 (SDF-1) and
its receptor CXCR-4 play an important role in the homing of HPCs. The aim of the present
study was to analyze SDF-1–induced actin polymerization and migration of HL-60 cells and
primary human CD34+ cells. MATERIALS AND METHODS: SDF-1–induced migration of …
to chemotactic stimulation is essential for their homing efficiency, eg, during stem cell
transplantation. Previous studies established that stromal cell–derived factor-1 (SDF-1) and
its receptor CXCR-4 play an important role in the homing of HPCs. The aim of the present
study was to analyze SDF-1–induced actin polymerization and migration of HL-60 cells and
primary human CD34+ cells. MATERIALS AND METHODS: SDF-1–induced migration of …
