Endothelium lining the coronary vasculature and the heart chambers is a dynamic sensor
that serves a variety of functions including bidirectional communications with cardiac
myocytes. Among endothelium-released factors, nitric oxide exerts multifactorial effects on
various cell types in the heart and may play a role in growth of the vasculature and
myocardial hypertrophy. This review summarizes new data regarding the endothelium-to-
myocyte signaling focusing on its role in regulation of cardiac hypertrophy through a nitric …