Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model
BS Coller, JD Folts, LE Scudder, SR Smith - 1986 - ashpublications.org
BS Coller, JD Folts, LE Scudder, SR Smith
1986•ashpublications.orgA murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which
blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established
animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of
0.7 to 0.8 mg/kg of the F (ab') 2 fragment of the antibody completely blocked new thrombus
formation despite multiple provocations, making it the most potent antithrombotic agent
tested in this model.
blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established
animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of
0.7 to 0.8 mg/kg of the F (ab') 2 fragment of the antibody completely blocked new thrombus
formation despite multiple provocations, making it the most potent antithrombotic agent
tested in this model.
Abstract
A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8 mg/kg of the F(ab')2 fragment of the antibody completely blocked new thrombus formation despite multiple provocations, making it the most potent antithrombotic agent tested in this model.
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