Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx: evidence for similarities in store-operated and calcium release …
HL Ong, KT Cheng, X Liu, BC Bandyopadhyay… - Journal of Biological …, 2007 - ASBMB
Store-operated calcium entry (SOCE) is a ubiquitous mechanism that is mediated by distinct
SOC channels, ranging from the highly selective calcium release-activated Ca 2+(CRAC)
channel in rat basophilic leukemia and other hematopoietic cells to relatively Ca 2+-
selective or non-selective SOC channels in other cells. Although the exact composition of
these channels is not yet established, TRPC1 contributes to SOC channels and regulation of
physiological function of a variety of cell types. Recently, Orai1 and STIM1 have been …
SOC channels, ranging from the highly selective calcium release-activated Ca 2+(CRAC)
channel in rat basophilic leukemia and other hematopoietic cells to relatively Ca 2+-
selective or non-selective SOC channels in other cells. Although the exact composition of
these channels is not yet established, TRPC1 contributes to SOC channels and regulation of
physiological function of a variety of cell types. Recently, Orai1 and STIM1 have been …
