Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia
SA Scott, T Kimura, WF Dong, R Ichinohasama… - Leukemia research, 2004 - Elsevier
Epigenetic silencing of downstream components of the transforming growth factor beta
pathway including the cyclin-dependent kinase inhibitors (CDKIs) p15INK4B, p27KIP1 and
p21CIP1 is implicated in the pathogenesis of some hematological malignancies. Loss of
p15INK4B expression due to promoter methylation occurs frequently in human T-cell acute
lymphoblastic leukemia (T-ALL) but the expression and methylation status of p27KIP1
remains to be characterized in T-ALL or T-cell lymphoblastic lymphoma (T-LBL). As well …
pathway including the cyclin-dependent kinase inhibitors (CDKIs) p15INK4B, p27KIP1 and
p21CIP1 is implicated in the pathogenesis of some hematological malignancies. Loss of
p15INK4B expression due to promoter methylation occurs frequently in human T-cell acute
lymphoblastic leukemia (T-ALL) but the expression and methylation status of p27KIP1
remains to be characterized in T-ALL or T-cell lymphoblastic lymphoma (T-LBL). As well …
