Regulation of TH17 cells in the mucosal surfaces
D Mucida, S Salek-Ardakani - Journal of Allergy and Clinical Immunology, 2009 - Elsevier
The mucosal surfaces represent the main intersection between jawed vertebrates and the
environment. The mucosal surface of the intestine alone forms the largest surface that is
exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the
body. Therefore, a protective immune activity must coexist with efficient regulatory
mechanisms to maintain a health status of these organisms. The discovery of a new lineage
of TH cells that produce IL-17 has provided valuable new insight into host defense and the …
environment. The mucosal surface of the intestine alone forms the largest surface that is
exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the
body. Therefore, a protective immune activity must coexist with efficient regulatory
mechanisms to maintain a health status of these organisms. The discovery of a new lineage
of TH cells that produce IL-17 has provided valuable new insight into host defense and the …
