Manganese superoxide dismutase attenuates cisplatin-induced renal injury: importance of superoxide
CA Davis, HS Nick, A Agarwal - Journal of the American Society of …, 2001 - journals.lww.com
Cisplatin is a potent chemotherapeutic agent that is used to treat many human malignancies.
Unfortunately, in addition to side effects such as ototoxicity, anaphylaxis, and bone marrow
suppression, a significant percentage of patients receiving cisplatin develop severe
nephrotoxicity. Mitochondrial dysfunction that is mediated via the generation of reactive
oxygen species has been implicated in the pathogenesis of cisplatin-induced renal injury.
To address the mechanism, it was hypothesized that overexpression of antioxidant …
Unfortunately, in addition to side effects such as ototoxicity, anaphylaxis, and bone marrow
suppression, a significant percentage of patients receiving cisplatin develop severe
nephrotoxicity. Mitochondrial dysfunction that is mediated via the generation of reactive
oxygen species has been implicated in the pathogenesis of cisplatin-induced renal injury.
To address the mechanism, it was hypothesized that overexpression of antioxidant …