Endoplasmic reticulum stress–associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis
H Liu, R Baliga - Journal of the American Society of Nephrology, 2005 - journals.lww.com
Reactive oxygen metabolites are important mediators in cisplatin-induced apoptosis in renal
tubular epithelial cells (LLC-PK1). Mitochondria have been implicated to play a principal role
in cisplatin-induced apoptosis. Caspase 12, an endoplasmic reticulum (ER)-specific
caspase, participates in apoptosis under ER stress. Cytochrome P450 system is crucial to
the generation of reactive oxygen metabolites and is present at high concentration in the ER.
The direct role of caspase 12 in any model of renal injury has not previously been described …
tubular epithelial cells (LLC-PK1). Mitochondria have been implicated to play a principal role
in cisplatin-induced apoptosis. Caspase 12, an endoplasmic reticulum (ER)-specific
caspase, participates in apoptosis under ER stress. Cytochrome P450 system is crucial to
the generation of reactive oxygen metabolites and is present at high concentration in the ER.
The direct role of caspase 12 in any model of renal injury has not previously been described …